Formulation of Lamun Extract Gel Ethosomes (Enhalus acoroides) as Brightness and Moisturizing Agents on The Skin

Formulasi Sediaan Gel Etosom Ekstrak Lamun (Enhalus acoroides) Sebagai Pencerah dan Pelembab Pada Kulit

Abstract

Seagrass is a flowering plant that lives in the sea and is found in almost all coastal areas. Seagrass (Enhalus acoroides) contains phenolic and flavonoid compounds, which are suitable as pigmentation agents due to tyrosinase inhibition. The ethanol extract from the seagrass plant is formulated into an ethosomal form to increase the compound's ability to penetrate the stratum corneum. This study aims to formulate a moisturizing gel preparation from the ethosome of seagrass plant extract (E. acoroides) on the skin that inhibits the tyrosinase enzyme so it can lighten the skin. Ethosomes were made using the cold process so that a good formula was made with the results of the characterization of the particle size of 216.1 nm measured using PSA. The seagrass extract ethosome was formulated into a gel and the properties, irritation index and gel activity test performed. The test of properties includes organoleptic, homogeneity, pH, viscosity and dispersibility. The test was performed on gels that had been stored at 4°C, 27°C and 40°C for two months. The irritation test was performed topically on male white rabbits. The results showed that all formulas had a good homogeneous appearance and were in the pH range of 5.38 to 5.80. The results of the activity test showed that the etosome gel of the seagrass extract had a moisturizing activity of 17% for one month using the preparation and the tyrosinase enzyme had an IC 50 of 175.91µ.g / mL inhibited.

Keywords: Enhalus acoroides, ethosomes, tyrosinase enzyme, moisturizing gel