Physical Characteristics and In Vitro Diffusion Rate of Domperidone Transdermal Patch using Methyl Methacrylate-Methacrylic Acid Derivative Polymers

Karakteristik Fisik dan Laju Difusi In Vitro Sediaan Transdermal Patch Domperidon Menggunakan Polimer Turunan Metil Metakrilat-Asam Metakrilat

Abstract

Transdermal patch formulation is the right choice to avoid the first-pass metabolism process of the active substance domperidone. This research aimed to determine the physical characteristics and in vitro diffusion rate of domperidone transdermal patch preparations made using two methyl methacrylate-methacrylic acid derivative polymer matrices, Eudragit E100 and Eudragit L 100-55. Domperidone transdermal patch preparations were prepared using the solvent evaporation method using variation concentrations of Eudragit E100 and Eudragit L100-55 from 5% to 20 %. Evaluation of the physical characteristics of the patch includes organoleptic, thickness, moisture content, weight uniformity, and folding resistance, and mechanical strength tests. The in vitro diffusion test was carried out by the flow-through method using a modified Franz diffusion cell. The transdermal patch with Eudragit E100 polymer showed good homogeneity without any domperidone crystallization obtained at concentrations of 10% (F2) and 20% (F3), while the transdermal patch with Eudragit L100-55 polymer showed good homogeneity only at a concentration of 20% (F6). The folding resistance and moisture content of the entire formula show results that meet the requirements. The percentage of elongation and tensile strength of the transdermal patch with Eudragit E100 polymer tended to increase with increasing polymer concentration, while the transdermal patch with Eudragit L100-55 polymer showed a decrease in the percentage of elongation and increase in tensile strength with increasing polymer concentration. A decrease in the in vitro diffusion rate of transdermal patches occurs when the polymer concentration is increased, such as in transdermal patches using Eudragit E100 or Eudragit L100-55.