https://jkk.unjani.ac.id/index.php/jkk/issue/feed 2026-08-12T21:18:28+08:00 Arie Hardian [email protected] Open Journal Systems <table class="mceItemTable" border="0" width="100%" cellspacing="0" cellpadding="0"> <tbody> <tr> <td valign="top" width="25%"> <p><img src="/public/site/images/jkkadmin1/cover_vol_3_no_2.JPG" width="259" height="372"></p> </td> <td valign="top" width="5%">&nbsp;</td> <td valign="top" width="70%"> <p align="justify"><strong>Jurnal Kartika Kimia (Kartika: Journal of Chemistry)</strong>&nbsp;is an open-access and peer-reviewed (double-blind) Scientific Journal that publishes all research articles/reviews/ short communication related to the progress of chemistry research.</p> <p align="justify">The focus of <strong>Jurnal Kartika Kimia&nbsp;(Kartika: Journal of Chemistry)</strong> is Pure and Applied Chemistry.&nbsp;</p> <p align="justify">The scope of this journal is:</p> <p align="justify">The scope in Pure Chemistry is 1) Analytical Chemistry, 2) Inorganic Chemistry, 3) Physical Chemistry, 4) Organic Chemistry, and 5) Biochemistry. The scope in Applied Chemistry is 1) Material Chemistry, 2) Environmental Chemistry, 3) Catalyst, 4) Food Chemistry, 5) Natural Products Chemistry, 6) Pharmaceutical Chemistry, 7) Medicinal Chemistry, and 8) Computational Chemistry.</p> <p align="justify"><strong>Jurnal Kartika Kimia&nbsp;(Kartika: Journal of Chemistry)</strong>&nbsp;is published by the Department of Chemistry, Faculty of Sciences and Informatics, University of Jenderal Achmad Yani in collaboration with Material and Environmental Development Center of Universitas Jenderal Achmad Yani. <strong>Jurnal Kartika</strong> <strong>Kimia&nbsp;(Kartika: Journal of Chemistry)</strong> publishes 2 issues per year in June and November.<strong> Jurnal Kartika Kimia&nbsp;(Kartika: Journal of Chemistry)</strong> can be accessed via print (<a href="https://portal.issn.org/resource/ISSN/2655-1322" target="_blank" rel="noopener">ISSN&nbsp;2655-1322</a>) and online (<a href="https://portal.issn.org/resource/ISSN/2655-0938" target="_blank" rel="noopener">ISSN 2655-0938</a>).</p> <p><strong>Jurnal Kartika Kimia</strong> has Sinta-2 accreditation based on the Ministry of Education, Culture, Research and Technology, Directorate General of Higher Education, Research, and Technology, Republic of Indonesia No: <a title="SK Akreditasi Sinta 2" href="https://drive.google.com/file/d/1MAqdg5DCRFRTRS9ZgvK3Jw9tKwcimG8P/view?usp=sharing" target="_blank" rel="noopener">10/C/C3/DT.05.00/2025</a>.</p> <p><a href="https://portal.issn.org/resource/ISSN/2655-1322" target="_blank" rel="noopener">p-ISSN:&nbsp;2655-1322</a></p> <p><a href="https://portal.issn.org/resource/ISSN/2655-0938" target="_blank" rel="noopener">e-ISSN:&nbsp;2655-0938</a></p> <p><img src="/public/site/images/jkkadmin1/e-ISSN_barcode.png"></p> </td> </tr> </tbody> </table> <p>&nbsp;</p> <p><strong>Jurnal Kartika Kimia</strong> indexed by&nbsp; :</p> <p><a href="https://scholar.google.co.id/citations?user=dGruSRoAAAAJ&amp;hl=id&amp;authuser=2" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/Google_Scholar1.png"></a>&nbsp;<a href="http://garuda.ristekdikti.go.id/journal/view/13727" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/Garuda1.png"></a>&nbsp;&nbsp;<a href="http://onesearch.id/Search/Results?filter[]=repoId:IOS6471" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/IOS.png"></a>&nbsp;<a href="http://moraref.kemenag.go.id/archives/journal/98077985952826272" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/Moraref.png"></a>&nbsp;<a href="https://www.neliti.com/journals/jurnal-kartika-kimia" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/neliti.png"></a>&nbsp;<a href="https://portal.issn.org/resource/ISSN/2655-0938" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/Road.png"></a>&nbsp;<a href="https://search.crossref.org/?q=jurnal+kartika+kimia" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/Crossref.png"></a>&nbsp;<a href="https://www.base-search.net/Search/Results?q=dccoll%3Aftjkartikakimia&amp;refid=dclink" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/Base.png"></a>&nbsp;<a href="https://app.dimensions.ai/discover/publication?search_mode=content&amp;and_facet_source_title=jour.1366084" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/Dimension1.png"></a>&nbsp;<a href="https://journals.indexcopernicus.com/search/journal/issue?issueId=all&amp;journalId=52324" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/ICI.png"></a>&nbsp;&nbsp;<a href="https://www.scilit.net/sources/95104" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/Scilit1.png"></a>&nbsp;&nbsp;<a href="https://www.worldcat.org/search?q=so%3AJurnal+Kartika+Kimia&amp;qt=advanced&amp;dblist=638" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/worldcat.png"></a>&nbsp;<a href="https://www.mendeley.com/profiles/kartika-journal-of-chemistry/" target="_blank" rel="noopener"><img src="/public/site/images/jkkadmin1/Mendeley.png"></a></p> <p>&nbsp;&nbsp;&nbsp;</p> <p>&nbsp;<strong>Supported by:</strong></p> <p><img src="/public/site/images/jkkadmin1/HKI.png">&nbsp;<img src="/public/site/images/jkkadmin1/HKBAI.png"></p> <p><a href="https://info.flagcounter.com/lhFf"><img src="https://s11.flagcounter.com/count2/lhFf/bg_FFFFFF/txt_000000/border_CCCCCC/columns_2/maxflags_10/viewers_0/labels_0/pageviews_0/flags_0/percent_0/" alt="Flag Counter" border="0"></a></p> <p><a title="Web Analytics" href="http://statcounter.com/" target="_blank" rel="noopener"><img src="//c.statcounter.com/11881976/0/5ab4623c/0/" alt="Web Analytics"></a> <a href="http://statcounter.com/p11881976/?guest=1">View My Stats</a></p> https://jkk.unjani.ac.id/index.php/jkk/article/view/1103 2026-06-19T09:52:23+08:00 Didi Prasetyo Benu [email protected] Cindy Claudia Christanti [email protected] I Gede Arya Wiguna [email protected] Fry Voni Steky [email protected] Veinardi Suendo [email protected]

Green synthesis strategies offer a sustainable approach for preparing semiconductor photocatalysts with tunable properties. In this study, ZnO particles were synthesized using shallot peel extract, and their structural, morphological, optical, and photocatalytic properties were systematically investigated. Structural characterization by Raman spectroscopy and X-ray diffraction confirmed the formation of phase-pure wurtzite ZnO, with crystallite sizes in the nanometer range. Scanning electron microscopy revealed hexagonal rod-like morphologies with dimensions of 1–2 μm, which are interpreted as polycrystalline assemblies of aggregated nanocrystallites. Optical analysis using UV–Vis diffuse reflectance spectroscopy showed a direct bandgap of 3.02 eV and additional visible-light absorption, which may be associated with defect states and possible extrinsic contributions. Photoluminescence spectroscopy exhibited green emission attributed to intrinsic defects. The photocatalytic performance of the synthesized ZnO was evaluated through the removal of Rhodamine B under irradiation, achieving a maximum removal efficiency of 97.68% within 150 min. Kinetic analysis indicated that the process follows a pseudo-first-order model with an apparent rate constant of 0.0290 min⁻¹. The observed photocatalytic performance may be associated with the structural and optical characteristics of the synthesized ZnO. However, the specific roles of these factors, as well as the contribution of adsorption, cannot be conclusively distinguished in the absence of a control sample. Overall, this study provides insight into the relationship between synthesis conditions and the resulting properties of green-synthesized ZnO, while highlighting the need for further investigation to clarify the underlying mechanisms. This work demonstrates that shallot peel extract is an effective and environmentally benign capping agent for engineering ZnO photocatalysts with high efficiency for wastewater treatment applications.

2026-05-31T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/915 2026-07-02T07:43:20+08:00 Willy Tirza Eden [email protected] Erlina Sari [email protected] Endah Widhihastuti [email protected] Tri Minarsih [email protected] Senda Kartika Rakainsa [email protected]

Antioxidants are compounds that can overcome the effects of free radicals. One of the plants that has antioxidant activity is the Porang plant (Amorphophallus muelleri). This study aims to determine the antioxidant activity of the Porang leaves’ ethanol extract and fraction using the DPPH method. Porang leaves were extracted using maceration with 96% ethanol and separated by fractionation using n-hexane and ethyl acetate. The ethanol extract and the three fractions were tested for their activity as antioxidants using the DPPH method with ascorbic acid as positive control. Phytochemical screening and Total Flavonoid Content (TFC) assay were also conducted. Phytochemical screening showed the presence of flavonoids, tannins/polyphenols, and terpenoids. Quantitative test for Total Flavonoid Content (TFC) showed that the greatest flavonoid content was found in the ethyl acetate fraction, which was 101.93 ± 2.75 mgQE/g. The results showed that the strongest antioxidant activity was possessed by ethanol extract (IC50 66.39 ± 0.44 µg/mL), followed by the ethyl acetate fraction (IC50 72.19 ± 4.37 µg/mL), ethyl acetate insoluble fraction (IC50 135.48 ± 2.54 µg/mL), and the weakest was n-hexane fraction (IC50 198.31 ± 16.75 µg/mL). Hence, cream was prepared using ethanol extract which possesses the strongest antioxidant activity. Formula 4 (7.5% extract) showed the strongest antioxidant activity (IC50 1,637.12 µg/mL), followed by formula 3 (5% extract) with IC50 of 2590.377 µg/mL, formula 2 (2.5% extract) with IC50 of 3,898.694 µg/mL, and formula 1 (cream base) with IC50 of 110,727.4 µg/mL. All cream formulations which contained porang leaves extract (F2 – F4) had higher antioxidant activity than formula 1 (base), although their antioxidant activity was classified as very weak.

2026-05-31T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1068 2026-05-31T22:59:52+08:00 Ni Luh Putu Yuniantari [email protected] Erlin Susilowati [email protected] Dini Nastiti Anjarsari [email protected]

Banyuwangi Regency is a major producer of citrus fruits; however, the peels and leaves are seldom utilized for high-value applications, leading to their accumulation as organic waste. One promising strategy to enhance the economic value of these by products is the extraction of essential oils from citrus peels. This study investigates the extraction of Jeruk Siam (Citrus nobilis) peels using the Soxhlet method with four different solvents: n-hexane, petroleum ether, chloroform, and ethanol. Two peel treatment conditions were employed: (1) fresh peels, and (2) air-dried peels stored for 14 days both of which were incubated at room temperature in the extractor before the extraction process. Gas Chromatography–Mass Spectrometry (GC-MS) analyzed indicated that the main terpenoid component in the peel extract was dl-limonene based on relative abundance, ranging from 23.94% to 58.90%, depending on the solvent which used and the initial treatment of the citrus peels. The results revealed that Soxhlet extraction of fresh citrus using chloroform produced an organic extract with relative abundance of dl-limonene, amounting to 58.90%.

2026-05-31T22:09:11+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1077 2026-07-02T07:45:03+08:00 Jeanne Dewi Damayanti [email protected] Maria Assumpta Nogo Ole [email protected] M. Ilham Nurdin [email protected] Arifah Sukasri [email protected] Nur Amin Riyadi [email protected]

Golden snails are widely recognized as significant pests in Indonesian rice fields because they damage young rice plants by attacking their stems and leaves. Despite their harmful agricultural impact, golden snail shells contain a high calcium carbonate (CaCO₃) content of approximately 60.56%, making them a valuable raw material for calcium oxide (CaO) production through calcination. In this study, golden snail shells were calcined at 700, 800, and 900°C for 5 hours. The resulting CaO materials were characterized using Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), and Brunauer Emmett Teller (BET) surface area analysis. The findings demonstrate that calcination temperature significantly influences the physicochemical properties of the produced CaO, particularly its surface area. Among the tested conditions, the sample calcined at 900°C exhibited the highest specific surface area of 244.5211 m²/g, indicating enhanced porosity and a greater number of potential active sites at elevated calcination temperatures.

2026-05-31T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1054 2026-07-02T17:51:32+08:00 Tarso Rudiana [email protected] Eneng Elda Ernawati [email protected] Ayu Sunayah [email protected] Nuzulia Romadlotun Nikmah [email protected] Hasanah Hasanah [email protected] Siti Sawalia [email protected] Lia Permatasari [email protected] Arini Khaerunnisa [email protected] Dimas Danang Indriatmoko [email protected] Swastika Oktavia [email protected] Siti Nurbayti [email protected] Muhammad Ihda Hamlu Liwatu Zein [email protected]

Gandaria (Bouea macrophylla) is a tropical plant containing phenolic and flavonoid compounds that can be used as antidiabetic. This study aims to identify secondary metabolite compounds in the ethanol extract of B. macrophylla seeds, determine the antidiabetic potential through inhibition of the α-glucosidase enzyme in vitro and in silico and determine the reduction in blood sugar levels in vivo. The ethanol extract of B. macrophylla seeds has a % yield of 31.74 with secondary metabolite content such as flavonoids, phenolics, alkaloids, saponins and triterpenoids. The results of the UPLCMS/MS analysis of the ethanol extract of B. macrophylla seeds contain 3,4-dihydroxymandelic acid, laricitrin and L-(-)-phenylalanine compounds and can inhibit the α-glucosidase enzyme with an IC50 value of 22.5627 µg/mL. In silico, L-(-)-fenilalanin and laricitrin compounds have the best free energy and inhibiton constant values for the inhibition of the α-glucosidase enzyme (PDB ID: 3L4Y). In vivo, the ethanol extract of B. macrophylla seeds can reduce blood sugar levels in alloxan-induced Mus muscullus mice by 63.0% at a dose of 500 mg/kg BW. Phenolic and flavonoid compounds are thought to play a role in inhibiting the α-glucosidase enzyme in vitro and in silico and in reducing blood sugar levels in mice.

2026-05-31T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1114 2026-07-04T20:30:29+08:00 Sal Prima Yudha S [email protected] Akhmad Ues [email protected] Agus M.H. Putranto [email protected] Muhamad Alvin Reagen [email protected] Muhammad Adli Afif [email protected] Jimmy Askhan [email protected] Lenon Jus Pentus Tarigan [email protected]

A study on the addition of natural in the form of Lerak (Sapindus rarak) fruit rinds extract (ESR and synthetic additives in the form of N,N-dimethylurea (DMU) compounds in the zinc electrodeposition process on iron plates was carried out at room temperature. The results of this study show that the electrodeposition of zinc in electrolyte solution treated with Sapindus rarak extract additive gives a more visually uniform and compact coating morphology based on optical microscopy observations coating product than the electrodeposition product without additive or using N,N-dimethylurea additive. This has been observed using the naked eye and supported by observations under an optical microscope. The existence of zinc coating on the surface of the iron plate is supported by an increase in material thickness (control: 0.051 mm), (DMU: 0.025 mm) and (ESR: 0.028 mm) and an increase in material weight (control: 0.085 g), (DMU: 0.074 g) and (ESR: 0.074 g). In conclusion, the addition of DMU and ESR reduced the thickness and mass gain compared with the additive-free control.

2026-05-31T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1062 2026-05-31T23:00:59+08:00 Rahel Sitompul [email protected] Sania Losiana Yomaki [email protected] Susilowati Susilowati [email protected] Faisal Faisal [email protected] Ramlah Ramlah [email protected] Yunita Pare Rombe [email protected] Hermawati Abubakar [email protected] Murtihapsari Murtihapsari [email protected]

African The Bitter Leaf plant (Vernonia amygdalina) is widely used in traditional medicine across tropical regions. This species possesses a diverse range of pharmacological properties, including antibacterial, antioxidant, and antidiabetic activities. These bioactivities are attributed to secondary metabolites synthesized through natural defense mechanisms, such as flavonoids, alkaloids, triterpenoids, tannins, saponins, and steroids. This research aimed to characterize the phytochemical profile of the plant using Fourier-Transform Infrared Spectroscopy (FTIR) and Gas Chromatography-Mass Spectrometry (GC-MS), alongside evaluating its antibacterial and antioxidant potential. Phytochemical screening of the ethyl acetate extract confirmed the presence of alkaloids, flavonoids, and triterpenoids. Bioactivity assays demonstrated that the ethyl acetate extract exhibits: strong antibacterial activity against Escherichia coli with an inhibition zone of 12.1 mm and very strong antibacterial activity against Staphylococcus aureus with an inhibition zone of 91 mm at a concentration of 1000 µg/mL. Moderate antioxidant activity: the extract yielded an IC50 value of 149.10 ppm. FTIR analysis identified functional groups including hydroxyl (O-H), aliphatic (C-H), and ether/alcohol (C-O) moieties. These findings were further corroborated by GC-MS analysis, which identified major terpenoid compounds such as Linalool (89,23%), Neral (86,06%), Neophytadiene (91,78%), 2,6-octadienal, 3,7-dimethyl-,(E) (95,93%), Phytol (96,86%) dan 6,11-Dimethyl-2,6,10-dodecatrien-1-ol (69,85%). These constituents are likely responsible for the observed antibacterial and antioxidant effects.

2026-05-31T22:47:09+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1087 2026-07-05T11:54:07+08:00 Sari Purbaya [email protected] Yenny Febriani Yun [email protected] Dara Santika [email protected] Yosephine Liliana Intan Danar Saputri [email protected] Fitria Rahma Dewi [email protected] Riana Zevanisa Arsyi [email protected] Dayu Yunita [email protected] Fahriani Istiqomah [email protected] Siska Elisahbet Sinaga [email protected]

Endophytic fungi are microorganisms that live within plant tissues and are capable of producing secondary metabolites with potential antibacterial, antifungal, and anticancer activities. This study aimed to isolate, identify, and evaluate the antibacterial activity of endophytic fungi from the stem of Bauhinia fulva Blume through isolation, morphological identification, fermentation, ethyl acetate extraction, phytochemical screening, and antibacterial testing using the disk diffusion method. The results showed that the isolated endophytic fungus was identified as Fusarium solani, producing 1.4095 g of ethyl acetate extract. Phytochemical screening revealed the presence of alkaloids, flavonoids, quinones, and triterpenoids/steroids. The ethyl acetate extract of F. solani exhibited antibacterial activity against Staphylococcus aureus with a maximum inhibition zone of 20.85 mm and lower activity against Escherichia coli with a maximum inhibition zone of 5.56 mm, indicating its potential as a natural source of antibacterial compounds.

2026-05-31T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1073 2026-08-12T21:18:28+08:00 Ali Kusrijadi [email protected] Zackiyah Zackiyah [email protected] Permata Maratussolihah [email protected]

The spoilage of marine products such as fresh shrimp is characterized by an increase in pH as a result of protein degradation which produces biogenic amines which are harmful if consumed. Simple early detection of damage can be done using smart packaging halochromic film. The purpose of this research is the synthesis, characterization and ability testing of smart packaging halochromic film is based on jali seed flour (Coix lacryma-jobi) embedded with anthocyanin pigments of Ruellia simplex flower extract (EBRS) as a natural indicator. There are two stages in the research method, the first stage includes the extraction and characterization of anthocyanins from Ruellia simplex flowers. The second stage is the synthesis, characterization and testing of the halochromic film capability of jali seed flour-EBRS film. Measuring Total Anthocyanin Content content in Ruellia simplex flowers extract uses the differential pH methods the anthocyanin is 1.037 mg/L. Sensitivity Test of Ruellia simplex Flower Extract to pH indicate contains pigments and is sensitive to changes in pH from 1-12, and gradual discoloration from magenta to purple, colorless, blue, green, and yellow. Smart packaging halochromic film were made using varying EBRS concentrations of 6%, 8%, and 10% (w/w), The ability of the EBRS halochromic film to change pH from 1 to 12 was obtained by the 8% EBRS halochromic film being the best in inform of discoloration. Characterization of 8% (w/w) EBRS halochromic film compared with standard film showed that the addition of EBRS reduced tensile strength values, increased solubility properties, swelling but did not affect the thickness and water rate transmission properties. The EBRS 8% (w/w) indicator film test showed that the indicator film was able to communicate early detection of shrimp damage.

2026-06-18T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/854 2026-07-05T20:54:50+08:00 Indra Lasmana Tarigan [email protected] Nadia Rahmasari [email protected] Chairanisa Intan Kartika [email protected] Jonathan Sabar Simorangkir [email protected] Ailsa Putri Dyanti [email protected] Muhammad Irfan Nur Widad [email protected]

Tuberculosis (TB) is a major infectious disease caused by Mycobacterium tuberculosis. Rifampicin is one of the primary anti-tuberculosis drugs; however, its clinical use is associated with gastrointestinal side effects and instability under acidic gastric conditions. Therefore, this study investigated the potential of an EDTA-functionalized ZSM-5 system as a rifampicin delivery carrier through an in silico approach. The study employed network pharmacology, Ramachandran analysis, molecular docking, toxicity prediction, and semi-realistic DFT-predicted electronic property analysis. Network pharmacology identified Cathepsin K (CTSK), BCL2, BCL2L1, and MCL1 as potential tuberculosis-related protein targets of rifampicin. Molecular docking showed that free rifampicin exhibited binding affinities of −9.1, −6.4, −9.7, −6.9, and −7.0 kcal/mol against CTSK, BCL2, BCL2L1, MCL1, and Mycobacterium tuberculosis, respectively. Meanwhile, the ZSM-5–EDTA–rifampicin complex showed binding affinities of −5.9, −5.6, −6.1, −6.0, and −7.3 kcal/mol, indicating that the complex maintained favorable interactions with tuberculosis-related targets. The proposed interaction model suggested that rifampicin could be retained within the porous ZSM-5 framework through hydrogen bonding and non-covalent interactions. In addition, the semi-realistic DFT-predicted HOMO–LUMO analysis indicated relatively stable electronic properties with an estimated energy gap of 4.34 eV. Toxicity prediction classified the rifampicin complex as mutagenic but non-carcinogenic. Overall, these findings suggest that the ZSM-5–EDTA system has potential as a controlled rifampicin delivery platform and may support further development of tuberculosis drug delivery systems.

2026-06-18T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1057 2026-07-10T05:19:36+08:00 Asniar Pascayantri [email protected] Hasnawati Hasnawati [email protected] Dian Munasari Solo [email protected] Nurramadhani A. Sida [email protected] Wa Ode Nurhayati Basri [email protected] Sarida Sarida [email protected] Aisyah Aisyah [email protected] Nurul Azizah Putri Herina [email protected] Muhammad Bagas Rahya Arafat [email protected]

Chromolaena odorata has traditionally been used to treat various diseases such as bacterial and fungal infections, external wounds, stomach ulcers, and vomiting blood. Its anticancer activity has been extensively studied. This study aims to prove the cytotoxic effect of Chromolaena odorata leaves on WiDr colon cancer cells and its inhibitory mechanism through cell cycle modulation. Dried Chromolaena odorata leaves were extracted by maceration using 96% ethanol. They were then triturated with n-hexane and ethyl acetate to obtain n-hexane and ethyl acetate fractions. The ethyl acetate fraction was then screened for phytochemicals using the tube method and tested for cytotoxicity using the MTT assay. The selectivity index (SI) was calculated by comparing the IC50 of WiDr cells to Vero cells. Cell cycle modulation was then observed using flow cytometry. The results showed that the ethyl acetate fraction of Chromolaena odorata leaves contained flavonoids, phenolics, and tannins, and was moderately cytotoxic to WiDr cells with an IC50 of 207.69 µg/mL,, with an SI of 3.5. The ethyl acetate fraction of Chromolaena odorata was able to inhibit the growth of WiDr colon cancer cell division through the G2/M and Sub G1 phases. Thus, it was concluded that the ethyl acetate fraction of Chromolaena odorata has great potential to be developed as a candidate source of colon anticancer agents.

2026-06-18T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1093 2026-08-12T20:13:38+08:00 Maura Vanessa [email protected] Nirwan Susianto [email protected] Aep Patah [email protected]

Ca2Al2SiO7:Pr3+ is a potential UV-C-emitting material due to its photoluminescence properties. In this study, Ca2Al2SiO7:Pr3+ was synthesized via the sol-gel method as an alternative to the solid-state reaction method, which is energy-intensive and often yields low-quality phases. The synthesized products appeared as white powders for the undoped samples and pale green powders for the Pr³⁺-doped samples. XRD characterization showed that the optimum synthesis conditions were achieved at pH 5 with a calcination duration of 10 hours, yielding the highest-quality phase. Optical and photoluminescence characterization revealed a maximum UV-C emission at 273 nm and a band gap energy of 3.92 eV at a Pr³⁺ doping concentration of 7.25% moles.

2026-06-18T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/736 2026-08-12T20:15:44+08:00 Deny Aditya Pratama [email protected] Dwi Saputri [email protected] Sani Sani [email protected] Lilik Suprianti [email protected]

Plastic waste continues to be an environmental issue in Indonesia, where the country ranks as the second-largest producer of plastic waste in the world. Bioplastics, derived from renewable materials such as starch, have the potential to serve as an alternative to conventional plastics. The objective of this research is to formulate biodegradable bioplastics utilizing sweet potato peel starch, carboxymethyl cellulose (CMC), and gum Arabic, with glycerol added as a plasticizer. Initially, extraction was performed to obtain starch from sweet potato peels. Subsequently, the bioplastic production process was carried out using the wet mixing followed by the casting method by mixing 5 grams of sweet potato starch with the CMC in various weights (0.1, 0.2, 0.3, 0.4, and 0.5 grams) and gum Arabic (1, 1.5, 2, 2.5, and 3 grams). Mechanical property tests were conducted to evaluate the quality of the bioplastics, including tensile strength, elongation, and apparent modulus. The results indicate that higher concentrations of CMC and gum Arabic enhance tensile strength and rigidity, with a maximum tensile strength of 1.51 MPa achieved. However, increasing CMC concentration can reduce elongation properties. The bioplastics exhibited water absorption ranging from 15.3% to 81.3%, while biodegradability tests demonstrated that samples reached degradation levels of up to 93.8% within 28 days. This study demonstrates that sweet potato peel starch, combined with CMC and gum Arabic, can produce bioplastics with favorable mechanical properties and environmental friendliness, thus presenting a potential alternative method for reducing plastic pollution in Indonesia.

2026-06-20T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1058 2026-08-12T20:20:05+08:00 Ari Sartinah [email protected] Yamin Yamin [email protected] Hasnawati Hasnawati [email protected] Suryani Suryani [email protected] Nur Illiyyin Akib [email protected] Hikmawati Supu [email protected]

This study aims to determine the total phenolic and flavonoid content of ethyl acetate fractions from pumpkin (Cucurbita moschata Durch.) and aibika (Abelmoschus manihot L.) leaves, and to evaluate the antioxidant activity of their combined fractions. Analysis of total phenolics and flavonoids content was carried out using UV-Vis spectrophotometry with gallic acid (phenolics) and quercetin (flavonoids) as standards. Antioxidant potential testing was carried out using the DPPH method. The results showed that the phenolics content of the ethyl acetate fraction of PLand ALwas 60.81 and 56.47 mgEAG/g, respectively, while the total flavonoids content of the ethyl acetate fraction of PLand ALwas 64.54 and 55.07 mgEK/g, respectively. The IC50 value of the combination of ethyl acetate fractions of PLand ALwith a ratio of 3:2 was 4.686 μg/mL, while the single ethyl acetate fractions of PLand ALwere 7.040 and 7.549 μg/mL, respectively. This indicates that increasing antioxidant activity can be done by combining fractions from two or more types of plants.

2026-06-20T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/968 2026-07-10T06:19:53+08:00 Adrianto Prihartantyo [email protected] Yulisa Lestari [email protected] Aga Nugraha [email protected] Labora Roma [email protected]

Biobriquettes serve as a renewable energy alternative with the potential to replace conventional charcoal while producing lower emissions. This study aimed to evaluate the effects of varying the ratio of raw material mixtures and the concentration of binder made from cassava starch on the quality of biobriquettes produced from candlenut shells (Aleurites moluccana) and empty palm oil fruit bunches (Elaeis guineensis jack). The selection of these raw materials was based on their abundant availability in Indonesia and their high lignocellulosic content. The biobriquettes were produced through a carbonization process, in which the candlenut shells were heated at 350°C for 30 minutes, while the palm oil empty fruit bunches were carbonized at 300°C for the same duration. The study applied variations in the composition ratios of candlenut shells to empty fruit bunches (100:0, 80:20, 60:40, 40:60, 20:80, and 0:100), as well as binder concentrations of 10%, 20%, and 30% (w/w) using cassava starch. The resulting biobriquettes were tested according to the Indonesian National Standard SNI 01-6235-2000 through proximate and physical analyses. The findings indicated that the variation.

2026-07-10T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1119 2026-08-12T06:35:29+08:00 Fadhila Nita Anugraheni [email protected] Qonitah Fardiyah [email protected] Barlah Rumhayati [email protected]

Waste from the batik industry has become increasingly abundant as the textile sector has grown. One significant pollutant in aquatic environments is the synthetic dye Remazol Red. This study investigates the removal of Remazol Red as a solution to mitigate environmental pollution. The method employed is coagulation-flocculation, using the synthetic coagulant FeCl3 modified with a natural flocculant, specifically chia seeds (Salvia hispanica L.). The research parameters included the type of acid (HCl, H2SO4, and HNO3), coagulant dosage, and flocculant dosage. The coagulation process was conducted at 700 rpm for 4 minutes, followed by flocculation at 50 rpm for 30 minutes. The results indicated that HCl yielded the highest removal percentage (98.98%). Furthermore, the optimum coagulant concentration resulted in 97.11% removal, while the optimum flocculant dose was 300 mg/L with a removal percentage of 98.57%. FTIR spectrophotometry characterization revealed that the sulfonate group (SO2) of Remazol Red and the Fe-Cl group in FeCl3 interacted with the carbonyl group (C=O) of the chia seeds.

2026-08-12T06:35:26+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1091 2026-07-12T06:55:01+08:00 Salma Muti Hafizha [email protected] Siti Aisyah [email protected] Asep Kadarohman [email protected]

Legume-based tempeh is a fermented food with the potential to support a healthy dietary pattern because it contains important nutritional components, including fatty acids. Germination and fermentation are known to influence lipid composition and fatty acid profiles in legumes, thereby potentially improving their nutritional value from a cardiovascular health perspective. This systematic review aimed to evaluate the effects of germination, fermentation, and their combination on the fatty acid profiles of legume-based tempeh. The PRISMA method was used to select and review 14 articles retrieved from the ScienceDirect and Scopus databases. The findings indicate that germination and fermentation can modify the fatty acid profile of tempeh, particularly through changes in saturated and unsaturated fatty acid contents. Several studies reported a decrease in saturated fatty acids and an increase in unsaturated fatty acids, including oleic acid, linoleic acid, and linolenic acid, although the magnitude of these changes varied depending on the type of legume, germination time, fermentation duration, microorganism, and analytical method used. Among the tempeh varieties reviewed, cowpea tempeh subjected to 24 h germination followed by 24 h fermentation showed a relatively favorable fatty acid profile, characterized by increased unsaturated fatty acids and an estimated linoleic acid to linolenic acid ratio of approximately 2.3:1.

2026-06-18T00:00:00+08:00 ##submission.copyrightStatement## https://jkk.unjani.ac.id/index.php/jkk/article/view/1101 2026-07-13T06:18:49+08:00 Gabrielle Callista Dwi Putri [email protected] Atiek Rostika Noviyanti [email protected] Yudha Prawira Budiman [email protected] Arie Hardian [email protected] Azman Bin Ma'Amor [email protected]

Hydroxyapatite (HA) has gained increasing attention as a biomimetic active ingredient in toothpaste due to its structural similarity to dental enamel and dentin, especially amid concerns over excessive fluoride exposure. This review discusses the role of HA in caries prevention and enamel remineralization, covering its antibacterial activity, physicochemical properties, synthesis strategies, and toothpaste applications. Evidence from in vitro, in situ, and clinical studies demonstrates that HA particularly in nano and ion-substituted forms effectively promotes enamel remineralization, enhances acid resistance, reduces dentin hypersensitivity, and exhibits antibacterial activity comparable or superior to fluoride toothpaste. However, challenges remain regarding nanoparticle stability, formulation consistency, and limited long-term clinical data. For HA to replace fluoride, it should be engineered as a reactive, well-dispersed nano-apatite (≤100 nm) with moderate-to-high crystallinity (~69–75%), stoichiometric Ca/P ratio of 1.67, and appropriate ionic substitution. Overall, HA represents a safe, biocompatible, and promising material for advanced toothpaste formulations.

2026-06-18T00:00:00+08:00 ##submission.copyrightStatement##